LBD
USP17L2 Antibody (C-term) [APR04131G]
- SKU:
- LBD-APR04131G
- Availability:
- Usually ships in 5 working days
Description
USP17L2 Antibody (C-term) [APR04131G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This USP17L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-503 amino acids from the C-terminal region of human USP17L2.
Cellular Localisation: Nucleus. Endoplasmic reticulum
Molecular Weight: 59619
Clone: Polyclonal
Gene Name: USP17L2
Gene ID: 377630
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.
Summary: Tissue Location: Broadly expressed..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, USP17L2