USP2 Antibody [AMM02572G]

USP2 Antibody [AMM02572G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, African Green Monkey

Specificity: This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623} Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}

Molecular Weight: 68072

Clone: Monoclonal

Gene Name: USP2

Gene ID: 9099

Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211) . Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity) . Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211) . Has no deubiquitinase activity against p53/TP53 (PubMed:17290220) . Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220) . Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254) . Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity) . Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity) . Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity) . Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity) .

Summary: Tissue Location: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Ubiquitin carboxyl-terminal hydrolase 2, 3.4.19.12, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41