USP4 Antibody (C-term) [APR31947G]

USP4 Antibody (C-term) [APR31947G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This USP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 903-933 amino acids from the C-terminal region of human USP4.

Cellular Localisation: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type

Molecular Weight: 108565

Clone: Polyclonal

Gene Name: USP4

Gene ID: 7375

Function: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403) . Deubiquitinates PDPK1 (PubMed:22347420) . Deubiquitinates TRIM21 (PubMed:16316627) . Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847) . May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234) . This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234) . May also play a role in the regulation of quality control in the ER (PubMed:16339847) .

Summary: Tissue Location: Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level) . Expressed in the hippocampal neurons

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Ubiquitin carboxyl-terminal hydrolase 4, Deubiquitinating enzyme 4, Ubiquitin thioesterase 4, Ubiquitin-specific-processing protease 4, Ubiquitous nuclear protein homolog, USP4, UNP, UNPH