VAC14 Antibody (N-Term) [APR11225G]

VAC14 Antibody (N-Term) [APR11225G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This VAC14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 125-159 amino acids from human VAC14.

Cellular Localisation: Endosome membrane. Microsome membrane {ECO:0000250|UniProtKB:Q80W92}. Note=Mainly associated with membranes of the late endocytic pathway

Molecular Weight: 87973

Clone: Polyclonal

Gene Name: VAC14

Gene ID: 55697

Function: Scaffold protein component of the PI (3, 5) P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3, 5-bisphosphate (PtdIns (3, 5) P2) . Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3- phosphate (PtdIns (3) P) and phosphatidylinositol 5-phosphate (PtdIns (5) P) (PubMed:33098764) . Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.

Summary: Tissue Location: Ubiquitously expressed.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:2000 IHC-P--1:100~500

Synonyms: Protein VAC14 homolog, Tax1-binding protein 2, VAC14, TAX1BP2, TRX