Valbenazine | B2954

Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2). VMAT2 plays an important role in the packaging of monoamines into presynaptic vesicles. Valbenazine shows Ki values of 110 and 150 nM in rat striatum homogenates and human platelets, respectively. It is selective for VMAT2 over serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B and dopamine D1 and D2 receptors. It is used for the treatment of tardive dyskinesia.

Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2). VMAT2 plays an important role in the packaging of monoamines into presynaptic vesicles. Valbenazine shows Ki values of 110 and 150 nM in rat striatum homogenates and human platelets, respectively. It is selective for VMAT2 over serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B and dopamine D1 and D2 receptors. It is used for the treatment of tardive dyskinesia.

B2954 | Valbenazine DataSheet

Alternate Name/Synonyms: [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate; NBI 98854; Ingrezza; L-Valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester

Appearance: Solid

Formulation:

CAS Number: 1025504-45-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₄H₃₈N₂O₄

Molecular Weight: 418.57

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~25 mg/ml in in DMSO, ~10 mg/ml in in Ethanol, ~30 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of VMAT2

MDL Number:

PubChem CID: 24795069

SMILES: CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC

InChi: InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1

InChi Key: GEJDGVNQKABXKG-CFKGEZKQSA-N