Valinomycin | 2238

A highly selective K⁺- ionophore. It binds potassium ions (K⁺) and facilitates their transfer across lipid bilayers. Inhibits Ca²⁺-ATPase activity and promotes cell death by mitochondrial swelling and autophagic processes, but not apoptosis. Antagonizes endothelin-induced vasoconstriction (IC₅₀ = 0.3 µM).

Valinomycin is a highly selective K+- ionophore

2238 | Valinomycin DataSheet

Alternate Name/Synonyms: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)

Appearance: White solid

Formulation: N/A

CAS Number: 2001-95-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅₄H₉₀N₆O₁₈

Molecular Weight: 1111.32

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO (25 mM) or EtOH (25 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A highly selective K⁺- ionophore

MDL Number: MFCD00005114

PubChem CID: 5649

SMILES: CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C

InChi: InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25 (7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)

InChi Key: FCFNRCROJUBPLU-UHFFFAOYSA-N