Valsartan | 2004

Cell-permeable. A high affinity angiotensin I receptor antagonist (Ki = 2.38 nM). Clinically useful antihypertensive agent. Active in vivo. Also, a recent study has shown that Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer’s disease.

Valsartan is a high affinity angiotensin I receptor antagonist (Ki = 2.38 nM). Clinically useful antihypertensive agent. Active in vivo. Also, a recent study has shown that Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer’s disease.

2004 | Valsartan DataSheet

Alternate Name/Synonyms: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-pentanamido]butanoic acid; CGP-48933

Appearance: White solid

Formulation: N/A

CAS Number: 137862-53-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₉N₅O₃

Molecular Weight: 435.52

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~ 25 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A high affinity angiotensin I receptor antagonist

MDL Number: MFCD00865840

PubChem CID: 60846

SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O

InChi: InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1

InChi Key: ACWBQPMHZXGDFX-QFIPXVFZSA-N