Vandetanib | 1751

A potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC₅₀ = 40 nM). This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC₅₀ = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC₅₀ = 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.

Vandetanib is a potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC₅₀ = 40 nM). This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC₅₀ = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC₅₀ = 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.

1751 | Vandetanib DataSheet

Alternate Name/Synonyms: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima

Appearance: White solid

Formulation: N/A

CAS Number: 443913-73-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₄BrFN₄O₂

Molecular Weight: 475.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (30 mg/ml) or EtOH (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent VEGFR kinase inhibitor

MDL Number: MFCD07772346

PubChem CID: 3081361

SMILES: CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

InChi: InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)

InChi Key: UHTHHESEBZOYNR-UHFFFAOYSA-N