VAPA Antibody (C-term) [APR10690G]

VAPA Antibody (C-term) [APR10690G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This VAPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-210 amino acids from the C-terminal region of human VAPA.

Cellular Localisation: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane {ECO:0000250|UniProtKB:Q9Z270}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.

Molecular Weight: 27893

Clone: Polyclonal

Gene Name: VAPA

Gene ID: 9218

Function: Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204) . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204) . With OSBPL3, may regulate ER morphology (PubMed:16143324) . May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470) .

Summary: Tissue Location: Ubiquitous.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Vesicle-associated membrane protein-associated protein A, VAMP-A, VAMP-associated protein A, VAP-A, 33 kDa VAMP-associated protein, VAP-33, VAPA, VAP33