VASH2 Antibody (C-term) [APR03891G]

VASH2 Antibody (C-term) [APR03891G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This VASH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the C-terminal region of human VASH2.

Cellular Localisation: Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Mainly localizes in the cytoplasm (PubMed:19204325) . Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312) . Associates with microtubules (PubMed:31235911)

Molecular Weight: 40450

Clone: Polyclonal

Gene Name: VASH2 (HGNC:25723)

Gene ID: 79805

Function: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869) . Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830) . Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325) . Plays a role in axon formation (PubMed:31235911) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Vasohibin-2, Vasohibin-like protein, VASH2, VASHL