VAV3 Antibody (C-term) [ApR04882G]

VAV3 Antibody (C-term) [ApR04882G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This VAV3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 768-802 amino acids from the C-terminal region of human VAV3.

Cellular Localisation: N/A

Molecular Weight: 97776

Clone: Polyclonal

Gene Name: VAV3

Gene ID: 10451

Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity) . May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2) -mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3) -mediated adhesion. Does not affect integrin beta-1 (ITGB1) -mediated adhesion (By similarity) .

Summary: Tissue Location: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Guanine nucleotide exchange factor VAV3, VAV-3, VAV3