BW
VCP (A346) polyclonal Antibody | BS3773
- SKU:
- BW-BS3773
- Availability:
- Usually ships in 5 working days
Description
VCP (A346) polyclonal Antibody | BS3773 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2) . The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: VCP (A346) polyclonal Antibody detects endogenous levels of VCP protein.
Molecular Weight: ~ 88 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: 15S Mg (2+) ATPase p97 subunit; ATPase p97; IBMPFD; MGC131997; MGC148092; MGC8560; TER ATPase; TERA; p97; transitional endoplasmic reticulum ATPase; valosin-containing protein; yeast Cdc48p homolog
Immunogen: Synthetic peptide, corresponding to amino acids 320-370 of Human VCP.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: