VDAC2 Antibody (N-term) [APR33236G]

VDAC2 Antibody (N-term) [APR33236G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This VDAC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-85 amino acids from the N-terminal region of human VDAC2.

Cellular Localisation: Mitochondrion outer membrane. Membrane. Note=May localize to non-mitochondrial membranes.

Molecular Weight: 31567

Clone: Polyclonal

Gene Name: VDAC2

Gene ID: 7417

Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity) . The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity) . The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity) . Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432) . Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432) .

Summary: Tissue Location: Expressed in erythrocytes (at protein level) (PubMed:27641616) . Expressed in all tissues examined (PubMed:8420959)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:2000

Synonyms: Voltage-dependent anion-selective channel protein 2, VDAC-2, hVDAC2, Outer mitochondrial membrane protein porin 2, VDAC2