VE Cadherin Antibody (CDH5) (N-term) [APR05057G]

VE Cadherin Antibody (CDH5) (N-term) [APR05057G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This VE Cadherin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the N-terminal region of human VE Cadherin.

Cellular Localisation: Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Molecular Weight: 87528

Clone: Polyclonal

Gene Name: CDH5

Gene ID: 1003

Function: Cadherins are calcium-dependent cell adhesion proteins (By similarity) . They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602) . This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity) . It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224) . Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity) . These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120) . Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120) .

Summary: Tissue Location: Endothelial tissues and brain.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:2000

Synonyms: Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5