VEGFR2/Flk-1 (phospho-Y1175) polyclonal Antibody | BS5039

VEGFR2/Flk-1 (phospho-Y1175) polyclonal Antibody | BS5039 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulinlike sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs) . On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-VEGFR2 (Y1175) polyclonal Antibody detects endogenous levels of VEGFR2 protein only when phosphorylated at Tyr1175.

Molecular Weight: ~ 150, 210 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: VEGFR-2; EC 2.7.10.1; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen; VEGFR2; 16542; Kdr; 6130401C07; Flk-1; Flk1; Krd-1; Ly73; VEGFR-2; VEGFR2; 3791; KDR; 191306; P35968; FLK1; VEGFR; VEGFR2;

Immunogen: N/A

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Tumor Angiogenesis,ErbB HER Signaling,ErbB HER Signaling,