VEZT Antibody | 7959

VEZT Antibody | 7959 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: VEZT antibody was raised against a 17 amino acid peptide near the center of human VEZT.
The immunogen is located within amino acids 480 - 530 of VEZT.

Research Area: Stem Cell

Tested Application: E, WB, IHC-P, IF

Application: VEZT antibody can be used for detection of VEZT by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.

Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 63, 68, 78, 81, 83, 86 kDa
Observed: 60 kDa

Validation: N/A

Isoform: N/A

Purification: VEZT antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: VEZT antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: VEZT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: VEZT Antibody: VEZATIN, Vezatin

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Vezatin (VEZT) is a transmembrane protein which localizes to adherens junctions and binds to myosin VIIA and the cadherin-catenins complex (1) . Expression of this gene in gastric cancer tissues is decreased due to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts (2) . VEZT has also been shown to be required for morphogenesis of the preimplantation mouse embryo (3) .