VGLL1 Polyclonal Antibody | E-AB-53198

VGLL1 Polyclonal Antibody | E-AB-53198 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Protein TONDU, TDU, TONDU, Transcription cofactor vestigial like protein 1, Transcription cofactor vestigial-like protein 1, Vestigial like 1, vestigial like 1 homolog (Drosophila), Vgl-1, VGL1, Vgll1, VGLL1

Application: WB, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Epigenetics and Nuclear Signaling

Background: The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human VGLL1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:2000-1:10000 ELISA 1:2000-1:20000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 29 kDa

Molecular Weight(Observed): Refer to figures