Vinblastine Sulfate | 1959

A plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent.

Vinblastine Sulfate is a plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis.

1959 | Vinblastine Sulfate DataSheet

Alternate Name/Synonyms: Vincaleukoblastine sulfate salt; VLB

Appearance: White solid

Formulation: N/A

CAS Number: 143-67-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₆H₅₈N₄O₉S.H₂SO₄

Molecular Weight: 909.05

Cell-Permeable?: No

Purity: ≥95% by HPLC

Solubilities: DMSO (~ 50 mg/ml) or Water (~ 10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A tubulin polymerrization inhibitor

MDL Number: MFCD00082457

PubChem CID: 241902

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

InChi: InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6, 36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2, 37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

InChi Key: KDQAABAKXDWYSZ-JKDPCDLQSA-N