Vorapaxar | B3304

Vorapaxar (SCH-530348) is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner. An anti-platelet agent.

Vorapaxar (SCH-530348) is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner. An anti-platelet agent.

B3304 | Vorapaxar DataSheet

Alternate Name/Synonyms: SCH-53034 Ethyl N-[(3R,3aS,4S,4aR,7R,8aR,9aR)-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridyl]vinyl]-3-methyl-1-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-3H-benzo[f]isobenzofuran-7-yl]carbamate SCH53034

Appearance: Crystalline solid

Formulation:

CAS Number: 618385-01-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₃FN₂O₄

Molecular Weight: 492.59

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >100 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A thrombin receptor (protease-activated receptor, PAR-1) antagonist

MDL Number:

PubChem CID: 10077130

SMILES: O=C(OCC)N[C@H](CC1)C[C@](C[C@]23[H])([H])[C@]1([H])[C@H](/C=C/C4=NC=C(C5=CC=CC(F)=C5)C=C4)[C@]2([H])[C@@H](C)OC3=O

InChi: InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1

InChi Key: ZBGXUVOIWDMMJE-QHNZEKIYSA-N