VR23 | B1515

VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.

VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.

B1515 | VR23 DataSheet

Alternate Name/Synonyms: 7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1624602-30-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₁₆ClN₅O₆S

Molecular Weight: 477.88

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 0.5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective proteasome inhibitor

MDL Number: N/A

PubChem CID: 73442847

SMILES: C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]

InChi: InChI=1S/C19H16ClN5O6S/c20-13-1-3-15-16(11-13)21-6-5-17(15)22-7-9-23(10-8-22)32(30,31)19-4-2-14(24(26)27)12-18(19)25(28)29/h1-6,11-12H,7-10H2

InChi Key: PDQVZPPIHADUOO-UHFFFAOYSA-N