VU 0364439 | 2815

VU-0364439 is a potent positive allosteric modulator (PAM) of mGluR-4 (metabotropic glutamate receptor) (EC₅₀ = 19.8 nM in vitro for human mGluR-4).

VU-0364439 is a potent positive allosteric modulator (PAM) of mGluR-4 (metabotropic glutamate receptor) (EC₅₀ = 19.8 nM in vitro for human mGluR-4).

2815 | VU 0364439 DataSheet

Alternate Name/Synonyms: N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1246086-78-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₃Cl₂N₃O₃S

Molecular Weight: 422.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent positive allosteric modulator (PAM) of mGluR-4 (metabotropic glutamate receptor)

MDL Number: N/A

PubChem CID: 46934289

SMILES: C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl

InChi: InChI=1S/C18H13Cl2N3O3S/c19-13-5-1-2-6-15(13)23-27(25,26)17-9-8-12(11-14(17)20)22-18(24)16-7-3-4-10-21-16/h1-11,23H,(H,22,24)

InChi Key: IXHCGJXBIHHIEF-UHFFFAOYSA-N