VX-222 | B2207

VX-222 is a potent, non-nucleoside inhibitor of HCV polymerase (IC₅₀ = 0.94-1.2 μM). It is 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.

VX-222 is a potent, non-nucleoside inhibitor of HCV polymerase (IC₅₀ = 0.94-1.2 μM). It is 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.

B2207 | VX-222 DataSheet

Alternate Name/Synonyms: 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid; Lomibuvir; VCH-222

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1026785-59-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₅NO₄S

Molecular Weight: 445.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, non-nucleoside inhibitor of HCV polymerase

MDL Number: N/A

PubChem CID: 24798764

SMILES: CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O

InChi: InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)

InChi Key: WPMJNLCLKAKMLA-UHFFFAOYSA-N