VX-765 | 2781

VX-765 is a prodrug of VRT-043198, a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 displays 100- to 10,000-fold selectivity against caspase-3 and -6 to -9. Exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18.

VX-765 is a prodrug of VRT-043198, a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 displays 100- to 10,000-fold selectivity against caspase-3 and -6 to -9. Exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18.

2781 | VX-765 DataSheet

Alternate Name/Synonyms: (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide; Belnacasan

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 273404-37-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₃₃ClN₄O₆

Molecular Weight: 508.99

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 200 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective caspase-1 inhibitor

MDL Number: N/A

PubChem CID: 11398092

SMILES: CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl

InChi: InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1

InChi Key: SJDDOCKBXFJEJB-MOKWFATOSA-N