VX-765 is a prodrug of VRT-043198, a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 displays 100- to 10,000-fold selectivity against...
VX-745 is a potent and selective inhibitor of p38α (IC₅₀ = 10 nM). It displays 22-fold greater selectivity versus p38β and no inhibition of p38γ. Also blocks TNFα production in LPS-stimulated HWB in...