BW
WASP (E284) polyclonal Antibody | BS1607
- SKU:
- BW-BS1607
- Availability:
- Usually ships in 5 working days
Description
WASP (E284) polyclonal Antibody | BS1607 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome at Xp11.23. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a 53 kDa proline-rich protein of unknown function designated WAS protein (WASP) . A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: WASP (E284) polyclonal Antibody detects endogenous levels of WASP protein.
Molecular Weight: ~ 53 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: IMD2; SCNX; THC; THC1; Thrombocytopenia 1 (X linked) ; U42471; Was; WASp; WASP; Wiskott Aldrich syndrome (eczema thrombocytopenia) ; Wiskott Aldrich syndrome protein; Wiskott-Aldrich syndrome protein;
Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human WASP.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: