WDR1 Antibody (C-term) [AMM08509G]

WDR1 Antibody (C-term) [AMM08509G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This WDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-577 amino acids from the C-terminal region of human WDR1.

Cellular Localisation: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome. Cell junction

Molecular Weight: 66194

Clone: Polyclonal

Gene Name: WDR1

Gene ID: 9948

Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004) . Enhances cofilin-mediated actin severing (By similarity) . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608) . Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity) . Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity) . Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565) .

Summary: Tissue Location: Expressed in peripheral blood mononuclear cells (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: WD repeat-containing protein 1, Actin-interacting protein 1, AIP1, NORI-1, WDR1