LBD
WDR45 Antibody (N-term) [APR31099G]
- SKU:
- LBD-APR31099G
- Availability:
- Usually ships in 5 working days
Description
WDR45 Antibody (N-term) [APR31099G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This WDR45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human WDR45.
Cellular Localisation: Preautophagosomal structure. Cytoplasm. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy
Molecular Weight: 39868
Clone: Polyclonal
Gene Name: WDR45
Gene ID: 11152
Function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066) . Binds phosphatidylinositol 3- phosphate (PtdIns3P) (PubMed:28561066) . Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066) . Together with WIPI1, promotes ATG2 (ATG2A or ATG2B) -mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P) -containing membranes (PubMed:31271352) . Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066) .
Summary: Tissue Location: Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta Expression is down-regulated in pancreatic and in kidney tumors
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat-containing protein 45, WDR45, WDRX1, WDRXI4, WIPI4