WDR45 Antibody (N-term) [APR31099G]

WDR45 Antibody (N-term) [APR31099G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This WDR45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human WDR45.

Cellular Localisation: Preautophagosomal structure. Cytoplasm. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy

Molecular Weight: 39868

Clone: Polyclonal

Gene Name: WDR45

Gene ID: 11152

Function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066) . Binds phosphatidylinositol 3- phosphate (PtdIns3P) (PubMed:28561066) . Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066) . Together with WIPI1, promotes ATG2 (ATG2A or ATG2B) -mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P) -containing membranes (PubMed:31271352) . Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066) .

Summary: Tissue Location: Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta Expression is down-regulated in pancreatic and in kidney tumors

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat-containing protein 45, WDR45, WDRX1, WDRXI4, WIPI4