WDR5 Antibody (C-term) [APR32971G]

WDR5 Antibody (C-term) [APR32971G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This WDR5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 321-354 amino acids from the C-terminal region of human WDR5.

Cellular Localisation: Nucleus

Molecular Weight: 36588

Clone: Polyclonal

Gene Name: WDR5

Gene ID: 11091

Function: Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960) . May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960) . As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245) . H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606) . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852) . May regulate osteoblasts differentiation (By similarity) . In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3