WFDC2 Antibody | 7459

WFDC2 Antibody | 7459 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Rabbit: (73%)

Immunogen: WFDC2 antibody was raised against a 16 amino acid peptide near the amino terminus of human WFDC2.
The immunogen is located within the first 50 amino acids of WFDC2 .

Research Area: Apoptosis

Tested Application: E, WB, IHC-P, IF

Application: WFDC2 antibody can be used for detection of WFDC2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: WFDC2 antibody is human specific. Multiple isoforms of WFDC2 are known to exist.

Positive Control 1: Cat. No. 1203 - A549 Cell Lysate

Positive Control 2: Cat. No. 10-101 - Human Lung Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 14 kDa
Observed: 20kDa

Validation: N/A

Isoform: N/A

Purification: WFDC2 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: WFDC2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: WFDC2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: WFDC2 Antibody : HE4, WAP5, EDDM4, dJ461P17.6, HE4, WAP four-disulfide core domain protein 2, Epididymal secretory protein E4

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The WAP four-disulfide core domain protein 2 (WFDC2) , also known as epididymal protein 4, is a member of the WFDC domain family, a family of proteins that is characterized by the presence of Whey Acidic Protein (WAP) domain, and is highly expressed in the lung and salivary gland (1, 2) . Members of this family include SLPI and elafin, antiproteinases involved in the innate immune system (2) . WFDC2 has been proposed to play a critical role in tumor formation and growth in ovarian cancer cells through the regulation of growth- and apoptosis-associated genes and may thus be a potential therapeutic target for epithelial ovarian cancer (3) .