Description
Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.
WHI-P131 selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.
Alternate Name/Synonyms: 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 202475-60-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₅N₃O₃
Molecular Weight: 297.31
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~50mg/ml
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A JAK3 inhibitor
MDL Number: MFCD11045992
PubChem CID: 3794
SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
InChi: InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChi Key: HOZUXBLMYUPGPZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |