WHI-P131 | 1853

Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.

WHI-P131 selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.

1853 | WHI-P131 DataSheet

Alternate Name/Synonyms: 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 202475-60-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₅N₃O₃

Molecular Weight: 297.31

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~50mg/ml

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A JAK3 inhibitor

MDL Number: MFCD11045992

PubChem CID: 3794

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

InChi: InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)

InChi Key: HOZUXBLMYUPGPZ-UHFFFAOYSA-N