Withaferin A | B2716

Withaferin A is a steroid lactone that displays potent anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.

Withaferin A is a steroid lactone that displays potent anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.

B2716 | Withaferin A DataSheet

Alternate Name/Synonyms: NSC 101088,5β,6β-epoxy-4β,22R,27-trihydroxy-1-oxo-δ-lactone-ergosta-2,24-dien-26-oic acid,NSC 273757

Appearance: White to off-white or slightly yellow crystalline solid

Formulation:

CAS Number: 5119-48-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₈O₆

Molecular Weight: 470.6

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~ 5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A steroidal lactone

MDL Number: MFCD10687098

PubChem CID: 265237

SMILES: CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO

InChi: InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChi Key: DBRXOUCRJQVYJQ-CKNDUULBSA-N