WNT7A Antibody [ApR04863G]

WNT7A Antibody [ApR04863G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This WNT7A antibody is generated from a rabbit immunized with a recombinant protein of human WNT7A.

Cellular Localisation: Secreted, extracellular space, extracellular matrix. Secreted

Molecular Weight: 39005

Clone: Polyclonal

Gene Name: WNT7A

Gene ID: 7476

Function: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity) . Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533) . Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314) . Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity) . Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity) . Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity) . Promotes formation of synapses via its interaction with FZD5 (By similarity) .

Summary: Tissue Location: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Protein Wnt-7a, WNT7A