Description
A third generation EGFR inhibitor. Selectively inhibits mutant EGFR T790M. Inhibits EGFR phosphorylation and induces siginificant tumor regressionin murine model of EGFR T790M. WZ4002 can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more effectively than Src inhibitors.
A third generation EGFR inhibitor. Selectively inhibits mutant EGFR T790M. Inhibits EGFR phosphorylation and induces siginificant tumor regressionin murine model of EGFR T790M.
Alternate Name/Synonyms: N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 1213269-23-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₇ClN₆O₃
Molecular Weight: 494.97
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An EGFR T790M inhibitor.
MDL Number: N/A
PubChem CID: 44607530
SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC
InChi: InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
InChi Key: ITTRLTNMFYIYPA-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |