Description
A Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
XAV939 is a Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
Alternate Name/Synonyms: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
Appearance: White solid
Formulation: N/A
CAS Number: 284028-89-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₁F₃N₂OS
Molecular Weight: 312.31
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (50 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Tankyrase (TNKS) inhibitor
MDL Number: MFCD16879017
PubChem CID: 2726824
SMILES: C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
InChi: InChI=1S/C14H11F3N2OS/c15-14(16, 17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18, 19,20)
InChi Key: KLGQSVMIPOVQAX-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |