XAV939 | 1727

A Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

XAV939 is a Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

1727 | XAV939 DataSheet

Alternate Name/Synonyms: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one

Appearance: White solid

Formulation: N/A

CAS Number: 284028-89-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₁F₃N₂OS

Molecular Weight: 312.31

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Tankyrase (TNKS) inhibitor

MDL Number: MFCD16879017

PubChem CID: 2726824

SMILES: C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F

InChi: InChI=1S/C14H11F3N2OS/c15-14(16, 17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18, 19,20)

InChi Key: KLGQSVMIPOVQAX-UHFFFAOYSA-N