LBD
XBP1 Antibody (C-term) [APR31018G]
- SKU:
- LBD-APR31018G
- Availability:
- Usually ships in 5 working days
Description
XBP1 Antibody (C-term) [APR31018G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This XBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the C-terminal region of human XBP1.
Cellular Localisation: Endoplasmic reticulum. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF) -dependent manner (PubMed:23529610) [Isoform 2]: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity) . {ECO:0000250|UniProtKB:O35426}
Molecular Weight: 28695
Clone: Polyclonal
Gene Name: XBP1 (HGNC:12801)
Gene ID: 7494
Function: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR) . Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity) . Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154) . Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923) . Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596) . Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity) .
Summary: Tissue Location: Expressed in plasma cells in rheumatoid synovium (PubMed:11460154) . Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941) . Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5, XBP1, TREB5, XBP2