XKR8 Antibody | 7965

XKR8 Antibody | 7965 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8.
The immunogen is located within the last 50 amino acids of XKR8.

Research Area: Apoptosis

Tested Application: E, WB, IHC-P, IF

Application: XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.

Positive Control 1: Cat. No. 1319 - Human Stomach Tissue Lysate

Positive Control 2: Cat. No. 10-801 - Human Stomach Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 43 kDa
Observed: 47 kDa

Validation: N/A

Isoform: N/A

Purification: XKR8 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: XKR8 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: XKR8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1) . XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1, 2) .