Y-27632, dihydrochloride | 1596

Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively. Prevents apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem cells (hES) without affecting their pluripotency.

Y-27632 is a selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively.

1596 | Y-27632, dihydrochloride DataSheet

Alternate Name/Synonyms: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride

Appearance: White soild

Formulation: N/A

CAS Number: 146986-50-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₂₁N₃O.2HCl

Molecular Weight: 320.26

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: H₂O (100 mM) or PBS (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Rho kinase (ROCK) inhibitor

MDL Number: MFCD03490488

PubChem CID: 9901617

SMILES: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

InChi: InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1

InChi Key: IDDDVXIUIXWAGJ-DDSAHXNVSA-N