Description
YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC₅₀ values of 1.0 and 0.57 µM, respectively. In functional assays, YM-90709 inhibits IL-5-prolonged eosinophil survival with an IC₅₀ value of 0.45 µM and does not affect the GM-CSF-prolonged eosinophil survival.
YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC₅₀ values of 1.0 and 0.57 µM, respectively.
Alternate Name/Synonyms: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Appearance: Yellow solid
Formulation: N/A
CAS Number: 163769-88-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₁N₃O₂
Molecular Weight: 359.43
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: YM-90709 is a novel, selective inhibitor of interleukin-5 (IL-5).
MDL Number: N/A
PubChem CID: 1103147
SMILES: CC1(CC2=CC(=C(C=C2C3=CC4=NC5=CC=CC=C5N=C4N31)OC)OC)C
InChi: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
InChi Key: HIXSPVQXXDULHS-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
