YM-90709 | B1074

YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC₅₀ values of 1.0 and 0.57 µM, respectively. In functional assays, YM-90709 inhibits IL-5-prolonged eosinophil survival with an IC₅₀ value of 0.45 µM and does not affect the GM-CSF-prolonged eosinophil survival.

YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC₅₀ values of 1.0 and 0.57 µM, respectively.

B1074 | YM-90709 DataSheet

Alternate Name/Synonyms: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline

Appearance: Yellow solid

Formulation: N/A

CAS Number: 163769-88-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁N₃O₂

Molecular Weight: 359.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: YM-90709 is a novel, selective inhibitor of interleukin-5 (IL-5).

MDL Number: N/A

PubChem CID: 1103147

SMILES: CC1(CC2=CC(=C(C=C2C3=CC4=NC5=CC=CC=C5N=C4N31)OC)OC)C

InChi: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3

InChi Key: HIXSPVQXXDULHS-UHFFFAOYSA-N