Z-VDVAD-FMK | 1142

A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-YVAD-FMK is a cell-permeable, irreversible caspase-2 inhibitor.

1142 | Z-VDVAD-FMK DataSheet

Alternate Name/Synonyms: Z-VDVAD-FMK, Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone)

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: N/A

Structure Available?: No

Peptide sequence: Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK

Salt Form: No

Molecular Formula: C₃₂H₄₆FN₅O₁₁

Molecular Weight: 695.7

Cell-Permeable?: Yes

Purity: Single spot by TLC

Solubilities: DMSO (20 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A caspase-2 inhibitor

MDL Number: MFCD03452881

PubChem CID: 25108684

SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34, 44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21-,22-,26-,27-/m0/s1

InChi Key: ANTIWMNLIROOQF-IREHUOSBSA-N