Z-VRPR-FMK | B1238

Z-VRPR-FMK is selective and irreversible MALT-1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor that inhibits NF- κB dependent gene expression affecting the growth, proliferation and survival of hyperactive B cell like in diffuse large B-cell lymphomas (ABC-DLBCL). It has also shown to inhibit autoprocessing activity of MCA2 in protozoan species

Z-VRPR-FMK is selective and irreversible MALT-1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor that inhibits NF- κB dependent gene expression affecting the growth, proliferation and survival of hyperactive B cell like in diffuse large B-cell lymphomas (ABC-DLBCL). It has also shown to inhibit autoprocessing activity of MCA2 in protozoan species

B1238 | Z-VRPR-FMK DataSheet

Alternate Name/Synonyms: Z-VRPR-FMK trifluoroacetate salt

Appearance: Off white solid

Formulation: N/A

CAS Number: 1381885-28-4 (free base)

Structure Available?: Yes

Peptide sequence: Z-VRPR-FMK

Salt Form: Yes

Molecular Formula: C₃₁H₄₉FN₁₀O₆.CF₃CO₂H

Molecular Weight: 790.81

Cell-Permeable?: Yes

Purity: ≥90% by HPLC

Solubilities: H₂O (~ 1 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A selective and irreversible MALT-1 inhibitor

MDL Number: N/A

PubChem CID: 121513848

SMILES: CC(C)C(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O

InChi: InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38);(H,6,7)/t21?,22-,23-,25-;/m0./s1

InChi Key: WIPHXOQUHDJLCU-WTJMUODPSA-N