ZC3HC1 (Phospho-S354) polyclonal Antibody | BS64402

ZC3HC1 (Phospho-S354) polyclonal Antibody | BS64402 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB

Application Range: WB: 1:500~1:1000

Background: NIPA (nuclear interaction partner of ALK) is an F-box-containing protein that is an essential component of the SCF-type E3 ligase (SCFNIPA) complex, a complex that controls the completion of S-phase and mitotic entry . This control is mediated by the ubiquitination and subsequent degradation of cell cycle regulatory proteins, whose oscillation of protein levels is required for proper cell cycle progression. Expression levels of NIPA are low in G0/G1 phases and upregulated in S and G2/M phases. The SCFNIPA complex targets nuclear cyclin B1 for ubiquitination in interphase, whereas phosphorylation of NIPA in late G2 phase and mitosis inactivates the complex to allow for accumulation of cyclin B1. NIPA may have an anti-apoptotic role in NPM-ALK-mediated signaling events.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ZC3HC1 (Phospho-S354) polyclonal Antibody detects endogenous levels of ZC3HC1 protein only when phosphorylated at Ser354.

Molecular Weight: ~ 65kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1; ZC3HC1; NIPA; HSPC216

Immunogen: Synthetic phosphopeptide derived from human ZC3HC1 around the phosphorylation site of Serine 354.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: