ZDHHC21 Antibody (N-term) [APR32133G]

ZDHHC21 Antibody (N-term) [APR32133G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This ZDHHC21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-87 amino acids from the N-terminal region of human ZDHHC21.

Cellular Localisation: Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q9D270}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Molecular Weight: 31385

Clone: Polyclonal

Gene Name: ZDHHC21 (HGNC:20750)

Gene ID: 340481

Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296) . Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (PubMed:22031296) . This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (PubMed:22031296) . Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity) .

Summary: Tissue Location: Widely expressed..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Palmitoyltransferase ZDHHC21, Zinc finger DHHC domain-containing protein 21, DHHC-21, ZDHHC21