ZFAND5 Polyclonal Antibody | E-AB-18321

ZFAND5 Polyclonal Antibody | E-AB-18321 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: AN1-type zinc finger protein 5, ZA20D2, ZFAN5, Zfand5, ZFAND5A, zinc finger A20 domain containing 2 , Zinc finger A20 domain containing protein 2 , Zinc finger A20 domain-containing protein 2, zinc finger AN1 type domain 5, Zinc finger protein 216, ZNF216

Application: WB, IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction

Background: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Concentration: 1.4 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 23 kDa

Molecular Weight(Observed): Refer to figures