Description
ZFAND5 Polyclonal Antibody | E-AB-18321 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: AN1-type zinc finger protein 5, ZA20D2, ZFAN5, Zfand5, ZFAND5A, zinc finger A20 domain containing 2 , Zinc finger A20 domain containing protein 2 , Zinc finger A20 domain-containing protein 2, zinc finger AN1 type domain 5, Zinc finger protein 216, ZNF216
Application: WB, IHC, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
Background: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Concentration: 1.4 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Full length fusion protein
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 23 kDa
Molecular Weight(Observed): Refer to figures