ZFP36L2 Antibody (Center) [APR04237G]

ZFP36L2 Antibody (Center) [APR04237G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This ZFP36L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human ZFP36L2.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P23949}. Cytoplasm {ECO:0000250|UniProtKB:P23949}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner {ECO:0000250|UniProtKB:P23949}

Molecular Weight: 51063

Clone: Polyclonal

Gene Name: ZFP36L2 (HGNC:1108)

Gene ID: 678

Function: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE) -containing mRNA transcripts by promoting their poly (A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510) . Acts as a 3'-untranslated region (UTR) ARE mRNA- binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868) . Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868) . Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510) . Promotes ARE- containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868) . Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) . Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Summary: Tissue Location: Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009) . Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2, Butyrate response factor 2, EGF-response factor 2, ERF-2, Protein TIS11D, ZFP36L2, BRF2, ERF2, RNF162C, TIS11D