ZFYVE20 Antibody (N-Term) [APR33174G]

ZFYVE20 Antibody (N-Term) [APR33174G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ZFYVE20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 41-65 amino acids from the human region of human ZFYVE20.

Cellular Localisation: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor Note=Enriched in endosomes that are in close proximity to clathrin- enriched regions at the cell surface.

Molecular Weight: 88870

Clone: Polyclonal

Gene Name: RBSN (HGNC:20759)

Gene ID: 64145

Function: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713) . Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000 WB--1:8000

Synonyms: Rabenosyn-5, 110 kDa protein, FYVE finger-containing Rab5 effector protein rabenosyn-5, RAB effector RBSN {ECO:0000312|HGNC:HGNC:20759}, Zinc finger FYVE domain-containing protein 20, RBSN (HGNC:20759)